Protein Details: Amiloride-sensitive sodium channel subunit delta

Protein ID

ICDB_Pro_0581

Protein Name

Amiloride-sensitive sodium channel subunit delta

Gene Name

SCNN1D; DNACH

Organism

Homo sapiens (Human)

Length

802 amino acids

AlphaFoldDB

AF-P51172-F1-model_v4.pdb

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water;which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney;colon;lung and sweat glands. Also plays a role in taste perception.

Sequence

MRAVLSQKTTPLPRYLWPGHLSGPRRLTWSWCSDHRTPTCRELGSPHPTPCTGPARGWPRRGGGPCGFTSAGHVLCGYPLCLLSGPIQGCGTGLGDSSMAFLSRTSPVAAASFQSRQEARGSILLQSCQLPPQWLSTEAWTGEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Intracranial Abscess and Potocki-Lupski Syndrome

Location

DOI ID

10.1074/jbc.270.46.27411; 10.1074/jbc.m512293200; 10.1165/rcmb.2009-0053oc; 10.1038/ng1285; 10.1038/nature04727; 10.1101/gr.2596504; 10.1152/ajplung.00331.2011; 10.1016/j.gene.2015.12.061

RefSeq

NP_001123885.2 [P51172-3]; XP_011540227.1; XP_011540234.1; XP_011540235.1